{"id":18448,"date":"2024-07-24T00:00:53","date_gmt":"2024-07-24T03:00:53","guid":{"rendered":"https:\/\/nogoyatimes.com\/?p=18448"},"modified":"2024-07-24T06:47:47","modified_gmt":"2024-07-24T09:47:47","slug":"desarrollan-vacuna-universal-contra-la-gripe-que-daria-proteccion-de-por-vida","status":"publish","type":"post","link":"https:\/\/nogoyatimes.com\/?p=18448","title":{"rendered":"Desarrollan vacuna universal contra la gripe que dar\u00eda protecci\u00f3n de por vida"},"content":{"rendered":"

Estar\u00eda disponible en 5 o 10 a\u00f1os<\/h2>\n

El equipo de investigadores valid\u00f3 su teor\u00eda usando el virus de 1918, que mat\u00f3 a millones de personas en todo el mundo. El proyecto estar\u00eda terminado y disponible en cinco o diez a\u00f1os<\/p>\n

Un nuevo enfoque prometedor para desarrollar una vacuna universal contra la gripe, que dar\u00eda inmunidad de por vida, fue creado por un equipo de investigadores que han validado su teor\u00eda usando el virus de la gripe de 1918.<\/p>\n

La investigaci\u00f3n que publica\u00a0Nature Communications<\/a>\u00a0indica que la vacuna gener\u00f3 adem\u00e1s \u201cuna s\u00f3lida respuesta inmunitaria en primates no humanos expuestos al virus H5N1 de la gripe aviar”.<\/p>\n

La vacuna no se bas\u00f3 en el virus H5N1, sino que los primates fueron inoculados contra el virus de la gripe de 1918, que mat\u00f3 a millones de personas en todo el mundo.<\/p>\n

El equipo encabezado por la Universidad de Ciencia y Salud de Oreg\u00f3n (OSHU), en Estados Unidos, indic\u00f3 que seis de once primates inoculados contra el virus de 1918 sobre vivieron al H5N1, mientras que en el grupo de control, no vacunado y expuesto al mismo virus, los seis murieron.<\/p>\n

El estudio plantea la posibilidad de desarrollar una vacuna protectora contra el H5N1 en las personas y que en \u201ccinco o diez a\u00f1os ser\u00e1 realista una vacuna \u00fanica contra la gripe”, se\u00f1al\u00f3 Jonah Sacha, de la OSHU y l\u00edder de la investigaci\u00f3n.<\/p>\n

El nuevo enfoque aprovecha una plataforma de vacunas desarrollada anteriormente por cient\u00edficos de la OHSU para combatir la tuberculosis y el VIH; de hecho ya se est\u00e1 utilizando en un ensayo cl\u00ednico contra el virus que causa el sida.<\/p>\n

El m\u00e9todo consiste en insertar peque\u00f1os fragmentos de pat\u00f3genos diana en el citomegalovirus (CMV), un virus de herpes com\u00fan que infecta a la mayor\u00eda de las personas a lo largo de su vida y suele producir s\u00edntomas leves o ninguno.<\/p>\n

El virus act\u00faa como un vector dise\u00f1ado espec\u00edficamente para inducir una respuesta inmunitaria de las c\u00e9lulas T del propio organismo.<\/p>\n

Este planteamiento difiere de las vacunas comunes, dise\u00f1adas para inducir una respuesta de anticuerpos dirigida a la evoluci\u00f3n m\u00e1s reciente del virus, que se distingue por la disposici\u00f3n de las prote\u00ednas que recubren la superficie exterior.<\/p>\n

La gripe no se trata de un solo virus, sino que evoluciona debido a que la prote\u00edna spike de su cubierta lo hace, por eso las vacunas var\u00edan cada a\u00f1o.<\/p>\n

Un tipo de c\u00e9lulas T de los pulmones, conocidas como c\u00e9lulas T efectoras de memoria, se dirigen a las prote\u00ednas estructurales internas del virus, en lugar de a su envoltura externa en continua mutaci\u00f3n.<\/p>\n

La estructura interna no cambia mucho con el tiempo, lo que supone un objetivo fijo para que las c\u00e9lulas T busquen y destruyan cualquier c\u00e9lula infectada por un virus de la gripe antiguo o reci\u00e9n evolucionado.<\/p>\n

Para probar su teor\u00eda de las c\u00e9lulas T, los investigadores dise\u00f1aron una vacuna basada en el CMV utilizando el virus de la gripe de 1918 como plantilla.<\/p>\n

El equipo expuso a los primates vacunados a aerosoles de part\u00edculas peque\u00f1as que conten\u00edan el virus de la gripe aviar H5N1, y seis de los once sobrevivieron.<\/p>\n

“Funcion\u00f3 porque la prote\u00edna interior del virus estaba muy bien conservada”, tanto, que incluso despu\u00e9s de casi cien a\u00f1os de evoluci\u00f3n, no puede cambiar esas partes fundamentalmente importantes de s\u00ed mismo, explic\u00f3 Sacha.<\/p>\n

La inhalaci\u00f3n del virus de la gripe H5N1 en aerosol provoca una cascada de acontecimientos que pueden desencadenar insuficiencia respiratoria, pero la inmunidad inducida por la vacuna fue suficiente para limitar la infecci\u00f3n y el da\u00f1o pulmonar, protegiendo a los monos de esa infecci\u00f3n tan grave.<\/p>\n

Adem\u00e1s Sacha cree que la plataforma podr\u00eda ser \u00ababsolutamente\u00bb \u00fatil contra otros virus mutantes, incluido el SARS-CoV-2. Fuente: El Once<\/p>\n

\"\"<\/p>\n

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Estar\u00eda disponible en 5 o 10 a\u00f1os El equipo de investigadores valid\u00f3 su teor\u00eda usando el virus de 1918, que mat\u00f3 a millones de personas en todo el mundo. El proyecto estar\u00eda terminado y disponible en cinco o diez a\u00f1os…<\/p>\n","protected":false},"author":2,"featured_media":18449,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,3,8,17],"tags":[],"class_list":["post-18448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-internacionales","category-noticias","category-salud","category-sociedad"],"yoast_head":"\nDesarrollan vacuna universal contra la gripe que dar\u00eda protecci\u00f3n de por vida - Nogoy\u00e1 Times<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nogoyatimes.com\/?p=18448\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desarrollan vacuna universal contra la gripe que dar\u00eda protecci\u00f3n de por vida - Nogoy\u00e1 Times\" \/>\n<meta property=\"og:description\" content=\"Estar\u00eda disponible en 5 o 10 a\u00f1os El equipo de investigadores valid\u00f3 su teor\u00eda usando el virus de 1918, que mat\u00f3 a millones de personas en todo el mundo. 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